Endocrine Abstracts

The IGFs are cellular modulators that play essential roles in the regulation of growth and development processes. Obviously, the action of IGF1 is depended on the activation of the specific receptor (IGF1R), which plays pivotal role in the growth as well as in the protection of cells against different apoptotic damages.The aim of the study was to examined the effect of IGF1, acted by its receptor, on apoptosis process in mice hepatic and cardiac cells tr...

Metabolic syndrome (MS) is characterized by low-grade inflammation and determined as an increased risk for cardiovascular disease. Recently, reports have demonstrated the antiinflammatory effects of statins. Often, the inhibitor of HMG-CoA reductase called atorvastatin was used in these experiments.Therefore, the aim of the present study was to test the effect of atorvastatin (10 mg/day) on growth factors (ghrelin, IGF1) levels in piglets with MS. The ch...